HC276 is known for its excellent corrosion resistance in various extremely aggressive media and harsh environments. It is a real super alloy among high nickel chromium molybdenum materials and is considered an outstanding alloy in the chemical industry.

 It can resist many of the harshest media encountered during chemical processing, including reducing and oxidizing acids. It has excellent resistance to sulfuric acid and hydrochloric acid, as well as excellent resistance to phosphoric acid. Controlled amount of tungsten and very high molybdenum content (up to 17%) C276 has excellent resistance to stress corrosion cracking and pitting corrosion. The seawater resistance of alloy C276 is also almost unparalleled, especially under cracking conditions, which can cause erosion of other commonly used materials, such as 316 stainless steel, 6MO stainless steel and Monel alloy. Hastelloy C276 is also favored by the oil and gas industry due to its ability to handle "sour" natural gas and the corrosion resistance of seawater. In such an environment, it has become very popular among valve and pump manufacturers.

Due to the high content of chromium and nickel in the alloy, tungsten and cobalt are added. C276 is difficult to process and the raw materials are expensive, but Hastelloy can produce unexpectedly high-quality compression fittings and valves.